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KMID : 0362320110360030196
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Journal of Korean Academy of Operative Dentistry
2011 Volume.36 No. 3 p.196 ~ p.202
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Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth
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Shin Su-Jung
Lee Woo-Cheol
Lee Jae-Il
Baek Seung-Ho
Kum Kee-Yeon
Son Won-Jun
Bae Kwang-Shik
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Abstract
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Objectives: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth.
Materials and Methods: Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05).
Results: MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients’ subjective pain levels and the r
esponse from percussion test were significantly related to SP level.
Conclusions: This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis.
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KEYWORD
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Canal exudate, MMP-8, SP, Pain
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